Endocrine Abstracts

Osterix (Osx) is an essential transcription factor for osteoblast differentiation and bone formation. Osx null mutants died perinatally with a complete absence of bone formation and Osx conditional knockouts in osteoblasts showed the osteopenic phenotype after birth. Even in Osx heterozygous mice with normal bone morphology, the reduced cortical thickness and osteoblast differentiation were observed by QCT and in vitro cell culture, respectively. This result exhibited t...

Introduction: This study aimed to examine whether altered Heart Rate Variability (HRV) could predict the risk of development of metabolic syndrome (MetSD) in Asians.Methods: We investigated health checkup records of 33 752 adults aged 20–65 years old who did health checkups and HRV measurement between April 2011 and June 2014 at Kangbuk Samsung Hospital, without MetSD, anemia, thyroid disease, malignancy, and heart disease. A 3-minute HRV recording ...

Background: The cardiovascular and metabolic outcomes of patients with AI are poor, and may be related to the non-physiological cortisol profile achieved with hydrocortisone treatment. Objectives: To describe salivary adrenal biomarkers, glucose and 24 hour ambulatory blood pressure (ABP) profiles, carotid intima media thickness (CIMT) and flow mediated dilatation (FMD) in CYP with primary AI, to improve knowledge of the relationship between non-physiolo...

Case history: A 26-year-old man was referred to the Endocrine Clinic due to lack of erections and infrequent shaving for 12 months. An extensive past medical history was noted, the majority of which was attributed to a diagnosis of cerebral palsy. Problems included feeding difficulties from birth with NG, followed by PEG feeding from age 3 to 20, gross motor, speech and language developmental delay, bilateral severe hearing impairment necessitating hearing aids, long sightedne...

Introduction: Adrenal venous sampling (AVS) is widely used when investigating primary hyperaldosteronism. In this study we reviewed adrenal aldosterone and cortisol values for measurement range and for biochemical concordance with intervention in patients being investigated for aldosterone producing adenoma (APA).Methods: Retrospective review of AVS procedures performed at our institution during three years (May 2016–May 2019) was conducted. Aldoste...

Introduction: Type 2 diabetes has a relationship with fatty liver. Fatty liver can progress to liver fibrosis. This study examined relationship between liver fibrosis and diabetes-related complications in type 2 diabetic patients.Methods: This study analyzed data from the 2007 to 2015 the Korea National Health and Nutrition Examination Survey (KNHANES) in South Korea. Which included values of c-peptide, fasting blood sugar, AST, ALT, and platelet to calc...

Background and aims: To evaluate the efficacy and safety of the newly developed dipeptidyl peptidase-4 (DPP-4) inhibitor evogliptin in drug-naïve patients with inadequately controlled type 2 diabetes.Materials and methods: In randomized, double-blind, placebo-controlled, parallel-group, multicenter, phase III study, 160 patients with type 2 diabetes were randomized to evogliptin 5 mg or placebo for 24 weeks. The primary efficacy outcome measure was ...

KML001 is an orally bioavailable and water soluble trivalent arsenic compound having anti-cancer activity via controlling the numerous signaling pathways including phosphoinositide 3-kinase (PI3K)/Akt and extracellular signal-regulated kinase (ERK) signaling pathways. PI3K/Akt and ERK signaling pathways are overactivated in adrenocorticotropic hormone (ACTH)-secreting pituitary adenoma. In this study, we evaluated the effects of KML001 on cell viability, cell cycle, apoptosis,...

Cigarette smoke contains over 60 well established carcinogens. There are strong links between some of these carcinogens and various types of smoking-induced cancers. In this study we investigated whether cigarette smoke extracts (CSEs) affects the cell proliferation, migration, and invasion of BG-1 human ovarian cancer cells by alteration of epithelial-mesenchymal transition (EMT). We confirmed that CSEs increased the ovarian cancer cell viability in a dose-dependent manner. A...

Background: Congenital hyperinsulinism (CHI) is the result of unregulated insulin secretion from the pancreatic β-cells leading to severe hypoglycaemia.1 Diazoxide is effective in virtually all forms of CHI except in those due to recessive (and some dominant) inactivating mutations in ABCC8 and KCNJ11 and in patients with focal CHI.2 We report a case of CHI with acute kidney injury secondary to diazoxide.Case ...